BDBM652949 (1R,9R)-6-(7- hydroxy-5- quinolinyl)- 10,10-dimethyl- 4-(2-(2- propenoyl)-2,6- diazaspiro[3,4] octan-6-yl)-3- azatricyclo [7.1.1.02,7]undeca- 2,4,6-triene-5- carbonitrile::US20240059703, Example 2-42::US20240059703, Example 2-46::US20240059703, Example 2-47
SMILES CC1(C)[C@@H]2C[C@H]1c1nc(N3CCC4(CN(C4)C(=O)C=C)C3)c(C#N)c(c1C2)-c1cc(O)cc2ncccc12
InChI Key InChIKey=WIGLPTORTKDYDZ-UUOWRZLLSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 652949
Affinity DataIC50: 28nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Affinity DataIC50: 181nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair