BDBM653706 US11911372, Example 129::US20240277683, Example 129::tert-Butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl)sulfamoyl)piperidine-1-carboxylate, 128 and N-(5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl)piperidine-4-sulfonamide hydrochloride, 129

SMILES COc1ccccc1-c1nnc(NS(=O)(=O)C2CCNCC2)s1

InChI Key InChIKey=HSIMUZOLAWAVDC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 653706   

TargetHistone acetyltransferase KAT6A [507-778](Human)
CTXT PTY

US Patent
LigandChemical structure of BindingDB Monomer ID 653706BDBM653706(tert-Butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadia...)
Affinity DataIC50: 2.09E+4nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
CTXT PTY

US Patent
LigandChemical structure of BindingDB Monomer ID 653706BDBM653706(tert-Butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadia...)
Affinity DataIC50: 2.09E+4nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

TargetHistone acetyltransferase KAT7 [325-611](Human)
CTXT PTY

US Patent
LigandChemical structure of BindingDB Monomer ID 653706BDBM653706(tert-Butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadia...)
Affinity DataIC50: 8.52E+4nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetHistone acetyltransferase KAT7 [325-611](Human)
CTXT PTY

US Patent
LigandChemical structure of BindingDB Monomer ID 653706BDBM653706(tert-Butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadia...)
Affinity DataIC50: 8.52E+4nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 653706BDBM653706(tert-Butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadia...)
Affinity DataIC50: 1.25E+5nMAssay Description:To determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 μL in 384-well low volu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 653706BDBM653706(tert-Butyl 4-(N-(5-(2-methoxyphenyl)-1,3,4-thiadia...)
Affinity DataIC50: 1.25E+5nMAssay Description:o determine the inhibition of KAT enzymatic activity by test compounds, assay reactions were conducted in a volume of 8 uL in 384-well low volume ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent