BDBM655364 US11912703, Example 166

SMILES Cc1c(-c2[nH]c3cnc(N4CCC(NC(C)C)CC4)c(F)c3c2C(C)C)cn2ncnc2c1C

InChI Key InChIKey=JDDCBHFMZPEBPQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 655364   

TargetToll-like receptor 8(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 655364BDBM655364(US11912703, Example 166)
Affinity DataIC50: 0.180nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 655364BDBM655364(US11912703, Example 166)
Affinity DataIC50: 0.410nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 9(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 655364BDBM655364(US11912703, Example 166)
Affinity DataIC50: 3.34E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent