BDBM656845 N-(2,2-Difluoroethyl)-5-fluoro-2-((4-(7-(((2S,5R)- 5-((4-fluoro-1-methyl-1H-pyrazole)-3- sulfonamido)tetrahydro-2H-pyran-2-yl)methyl)-2,7- diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)-N- isopropylbenzamide::US11919901, Compound 241

SMILES CC(C)N(CC(F)F)C(=O)c1cc(F)ccc1Oc1cncnc1N1CC2(C1)CCN(C[C@@H]1CC[C@H](CO1)NS(=O)(=O)c1nn(C)cc1F)CC2

InChI Key InChIKey=UAJRAGKAFOFHBJ-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 656845   

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Syndax Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 656845BDBM656845(N-(2,2-Difluoroethyl)-5-fluoro-2-((4-(7-(((2S,5R)-...)
Affinity DataKi: <1nMAssay Description:Table 4: For Ki determination, individual compounds were prepared as 10 mM DMSO stock solutions. Considering DMSO as the vehicle in the assay system....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2024
Entry Details
US Patent