BDBM657117 2-(3-(5-Amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-2-yl)-4-(methyl-d3)phenyl)-1,1,1,4,4,4-hexafluorobutane-2,3-diol::US11926616, Example 20::US11926616, Example 21

SMILES [2H]C([2H])([2H])c1ccc(cc1-c1cnc(N)c(n1)-c1c[nH]nc1C)C(O)(C(O)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=VYUPYMVMKRAEMM-FIBGUPNXSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 657117   

LigandPNGBDBM657117(2-(3-(5-Amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-...)
Affinity DataIC50: 100nMAssay Description:PI3Kδ (p110δ/p85α) Recombinant Human Protein was purchased from Eurofins (St Charles, MO). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657117(2-(3-(5-Amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM657117(2-(3-(5-Amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-...)
Affinity DataIC50: 100nMAssay Description:PI3Kγ (p110γ) Recombinant Human Protein was purchased from Life technology (Grand Island, NY). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657117(2-(3-(5-Amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-...)
Affinity DataIC50: 100nMAssay Description:PI3Kγ (p110γ) Recombinant Human Protein was purchased from Life technology (Grand Island, NY). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657117(2-(3-(5-Amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM657117(2-(3-(5-Amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM657117(2-(3-(5-Amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-...)
Affinity DataIC50: 500nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM657117(2-(3-(5-Amino-6-(3-methyl-1H-pyrazol-4-yl)pyrazin-...)
Affinity DataIC50: 500nMAssay Description:PI3Kδ (p110δ/p85α) Recombinant Human Protein was purchased from Eurofins (St Charles, MO). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent