BDBM657143 3-Amino-6-(2-methyl-5-(1,1,1-trifluoro-2,3-dihydroxy-3-methylbutan-2-yl)phenyl)-N-(tetrahydro-2H-pyran-4-yl)pyrazine-2-carboxamide::US11926616, Example 22

SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC1CCOCC1)C(O)(C(C)(C)O)C(F)(F)F

InChI Key InChIKey=AJFLVKVDUNNCQS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 657143   

LigandPNGBDBM657143(US11926616, Example 22 | 3-Amino-6-(2-methyl-5-(1,...)
Affinity DataIC50: 100nMAssay Description:PI3Kγ (p110γ) Recombinant Human Protein was purchased from Life technology (Grand Island, NY). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657143(US11926616, Example 22 | 3-Amino-6-(2-methyl-5-(1,...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM657143(US11926616, Example 22 | 3-Amino-6-(2-methyl-5-(1,...)
Affinity DataIC50: 500nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM657143(US11926616, Example 22 | 3-Amino-6-(2-methyl-5-(1,...)
Affinity DataIC50: 500nMAssay Description:PI3Kδ (p110δ/p85α) Recombinant Human Protein was purchased from Eurofins (St Charles, MO). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent