BDBM657147 (3-(3-Amino-6-(2-methyl-5-(1,1,1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazin-2-yl)cyclobutyl)(3-hydroxyazetidin-1-yl)methanone::US11926616, Example 24

SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C1CC(C1)C(=O)N1CC(O)C1)C(O)(CO)C(F)(F)F

InChI Key InChIKey=RCMBRLOOSOCPLT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 657147   

LigandPNGBDBM657147(US11926616, Example 24 | (3-(3-Amino-6-(2-methyl-5...)
Affinity DataIC50: 100nMAssay Description:PI3Kγ (p110γ) Recombinant Human Protein was purchased from Life technology (Grand Island, NY). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657147(US11926616, Example 24 | (3-(3-Amino-6-(2-methyl-5...)
Affinity DataIC50: 500nMAssay Description:PI3Kδ (p110δ/p85α) Recombinant Human Protein was purchased from Eurofins (St Charles, MO). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent