BDBM657153 3-Amino-N-((1S,2S)-2- hydroxycyclohexyl)-6-(2-(methyl-d3)-5- ((S)-1,1,1-trifluoro-2,3-dihydroxypropan-2- yl)phenyl)pyrazine-2-carboxamide, trifluoroacetate salt (single enantiomer)::3-Amino-N-((1S,2S)-2-hydroxycyclohexyl)-6-(2-(methyl-d3)-5-((S)-1,1,1-trifluoro-2,3-dihydroxypropan-2-yl)phenyl)pyrazine-2-carboxamide::US11926616, Example 27

SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@H]1CCCC[C@@H]1O)[C@](O)(CO)C(F)(F)F

InChI Key InChIKey=NLIIHZCKEGAEGL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 657153   

LigandPNGBDBM657153(US11926616, Example 27 | 3-Amino-N-((1S,2S)-2-hydr...)
Affinity DataIC50: 100nMAssay Description:PI3Kγ (p110γ) Recombinant Human Protein was purchased from Life technology (Grand Island, NY). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657153(US11926616, Example 27 | 3-Amino-N-((1S,2S)-2-hydr...)
Affinity DataIC50: 500nMAssay Description:PI3Kδ (p110δ/p85α) Recombinant Human Protein was purchased from Eurofins (St Charles, MO). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent