BDBM657178 (3-Amino-6-(5-((S)-1,1-difluoro-2,3- dihydroxypropan-2-yl)-2- methylphenyl)pyrazin-2-yl)((R)-2- (hydroxymethyl)pyrrolidin-1-yl)methanone, trifluoroacetate salt (single enantiomer)::(3-Amino-6-(5-((S)-1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-methylphenyl)pyrazin-2-yl)((R)-2-(hydroxymethyl)pyrrolidin-1-yl)methanone::US11926616, Example 45

SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N1CCC[C@@H]1CO)[C@](O)(CO)C(F)F

InChI Key InChIKey=BAHHZBALSVQCMS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 657178   

LigandPNGBDBM657178(US11926616, Example 45 | (3-Amino-6-(5-((S)-1,1-di...)
Affinity DataIC50: 100nMAssay Description:PI3Kγ (p110γ) Recombinant Human Protein was purchased from Life technology (Grand Island, NY). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657178(US11926616, Example 45 | (3-Amino-6-(5-((S)-1,1-di...)
Affinity DataIC50: 2.00E+3nMAssay Description:PI3Kδ (p110δ/p85α) Recombinant Human Protein was purchased from Eurofins (St Charles, MO). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent