BDBM657181 3-Amino-N-(4-cyanobicyclo[2.1.1]hexan-1-yl)-6-(5-(1,1-difluoro-2,3-dihydroxypropan-2-yl)-2-methylphenyl)pyrazine-2-carboxamide::US11926616, Example 48

SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC12CC(C1)(CC2)C#N)C(O)(CO)C(F)F

InChI Key InChIKey=IKZUFSZBLSBKSQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 657181   

LigandPNGBDBM657181(3-Amino-N-(4-cyanobicyclo[2.1.1]hexan-1-yl)-6-(5-(...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM657181(3-Amino-N-(4-cyanobicyclo[2.1.1]hexan-1-yl)-6-(5-(...)
Affinity DataIC50: 100nMAssay Description:PI3Kγ (p110γ) Recombinant Human Protein was purchased from Life technology (Grand Island, NY). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657181(3-Amino-N-(4-cyanobicyclo[2.1.1]hexan-1-yl)-6-(5-(...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM657181(3-Amino-N-(4-cyanobicyclo[2.1.1]hexan-1-yl)-6-(5-(...)
Affinity DataIC50: 100nMAssay Description:PI3Kδ (p110δ/p85α) Recombinant Human Protein was purchased from Eurofins (St Charles, MO). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent