BDBM658049 5-chloro-N-[2,4-difluoro-3-[1-(1H-imidazol-2-yl)imidazo[1,5-a]pyridin-6-yl]phenyl]-2-methoxypyridine-3-sulfonamide ::US20240083897, Compound 2
SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(c1F)-c1ccc2c(ncn2c1)-c1ncc[nH]1
InChI Key InChIKey=JVXMCRWYDRLMDG-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 658049
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GCN2 (unknown origin) using GFP-eIF2alpha as substrate incubated for 1.5 hrs in presence of ATP by plate reader analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Activation of GCN2 in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by halofuginone addition and measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:GCN2 protein was obtained from Carna Biosciences (cat #05-153). The protein was diluted in assay buffer (ThermoFisher Scientific, #PV6135), 2 mM dith...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Pharmaron UK Ltd.
Curated by ChEMBL
Pharmaron UK Ltd.
Curated by ChEMBL
Affinity DataEC50: 1.70E+3nMAssay Description:Activation of PERK in HEK293 cells transfected with ATF4 response element preincubated for 30 mins followed by tunicamycin addition and measured afte...More data for this Ligand-Target Pair