BDBM658474 1-((1R,5R,6S)-6-methyl-6-((6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)-2-azabicyclo[3.2.0]heptan-2-yl)prop-2-en-1-one 1-((1S,5S,6R)-6-methyl-6-((6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)-2-azabicyclo[3.2.0]heptan-2-yl)prop-2-en-1-one::US20240083900, Example 190

SMILES Cn1cc(cn1)-c1cn2nccc2c(O[C@@]2(C)C[C@@H]3[C@H]2CCN3C(=O)C=C)n1

InChI Key InChIKey=RZOINIBREFUBMF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 658474   

TargetTyrosine-protein kinase BTK(Human)
Biogen Research and Development

Curated by ChEMBL
LigandPNGBDBM658474(US20240083900, Example 190 | 1-((1R,5R,6S)-6-methy...)
Affinity DataKd:  0.310nMAssay Description:Inhibition of human full-length wild type BTK (M1 to S659 residues) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Biogen Research and Development

Curated by ChEMBL
LigandPNGBDBM658474(US20240083900, Example 190 | 1-((1R,5R,6S)-6-methy...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent