BDBM659401 6-(difluoromethyl)-8-(2,6-diazaspiro[3.4]octan-2-yl)-N-(1-((6-(trifluoromethyl)pyridin-3-yl)sulfonyl)piperidin-4-yl)quinazolin-2-amine::US20240092761, Compound 97

SMILES FC(F)c1cc(N2CC3(C2)CCNC3)c2nc(NC3CCN(CC3)S(=O)(=O)c3ccc(nc3)C(F)(F)F)ncc2c1

InChI Key InChIKey=TVEPQQPYQRCCBV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 659401   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659401(US20240092761, Compound 97 | 6-(difluoromethyl)-8-...)
Affinity DataIC50: 200nMAssay Description:In a CHEF assay, phosphorylation of a peptide substrate results in proportional increase in fluorescence. CHEF kinase assay use peptide substrates co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659401(US20240092761, Compound 97 | 6-(difluoromethyl)-8-...)
Affinity DataIC50: 200nMAssay Description:The luminescent signal generated is proportional to the ADP concentration produced and is correlated with the kinase activity. CDK1/Cyclin B1 was pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659401(US20240092761, Compound 97 | 6-(difluoromethyl)-8-...)
Affinity DataIC50: 200nMAssay Description:CDK6/Cyclin D3 catalyzes the production of ADP from ATP. ADP-Glo assay monitors ADP producing biochemical reactions. ADP-Glo is performed in 2 steps ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM659401(US20240092761, Compound 97 | 6-(difluoromethyl)-8-...)
Affinity DataIC50: 200nMAssay Description:ADP-Glo is performed in 2 steps upon completion of kinase reaction: a combined termination of kinase reaction and depletion of remaining ATP in the f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
US Patent