BDBM662985 Synthesis of 7-chloro-1-(2-chlorophenyl)-4-(prop-2-yn-1-ylamino)quinazolin-2(1H)-one ::US20240109880, Compound 10
SMILES COc1cccc(OC)c1S(=O)(=O)Nc1noc2cc(Cn3cccn3)c3CCOc3c12
InChI Key InChIKey=BYICTVGRFYUHAA-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 662985
Affinity DataIC50: 0.600nMAssay Description:a. The prepared enzyme solution was added to a 384-well plate at 3 μL/well, and 3 μL of 1× assay buffer was added to each well in columns 23 and 24 (...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:a. 1× buffer 2: 50 mM Tris-HCl, pH 7.8; 0.1 mM EDTA; 0.01% v/v tween-20; 1 mM DTT; 0.01% m/v bovine serum albumin.b. KAT6B enzyme solution: 3 nM (fin...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of KAT6A enzymatic activity by test compounds was determined using a radiometric 384-well format assay. A 10-point serial dilution of the ...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:TR-FRET is homogeneous proximity assay where Europium-labelled anti-acetyl lysine antibody binds to the acetylated substrate labelled with biotin whi...More data for this Ligand-Target Pair