BDBM662990 Synthesis of N-(5-((1H-pyrazol-1-yl)methyl)-3,4-dihydro-2H-chromeno [8,7-d]isoxazol-9-yl)-2-methoxybenzenesulfonamide ::US20240109880, Compound 15

SMILES COc1ccccc1S(=O)(=O)Nc1noc2cc(Cn3cccn3)c3CCCOc3c12

InChI Key InChIKey=MYPVOBDOIGALRI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 662990   

TargetHistone acetyltransferase KAT6A(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM662990(Synthesis of N-(5-((1H-pyrazol-1-yl)methyl)-3,4-di...)
Affinity DataIC50: 0.5nMAssay Description:a. The prepared enzyme solution was added to a 384-well plate at 3 μL/well, and 3 μL of 1× assay buffer was added to each well in columns 23 and 24 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT6B(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM662990(Synthesis of N-(5-((1H-pyrazol-1-yl)methyl)-3,4-di...)
Affinity DataIC50: 1.40nMAssay Description:a. 1× buffer 2: 50 mM Tris-HCl, pH 7.8; 0.1 mM EDTA; 0.01% v/v tween-20; 1 mM DTT; 0.01% m/v bovine serum albumin.b. KAT6B enzyme solution: 3 nM (fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2025
Entry Details
US Patent

TargetHistone acetyltransferase KAT6A [507-778](Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM662990(Synthesis of N-(5-((1H-pyrazol-1-yl)methyl)-3,4-di...)
Affinity DataIC50: 5nMAssay Description:Inhibition of KAT6A enzymatic activity by test compounds was determined using a radiometric 384-well format assay. A 10-point serial dilution of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent