BDBM663025 Synthesis of N-(6-((1H-pyrazol-1-yl)methyl)-4-(fluoromethoxy)benzo[d] isoxazol-3-yl)-6-(difluoromethyl)-2,4-dimethoxypyridine-3-sulfonamide ::US20240109880, Compound 50

SMILES COc1cc(nc(OC)c1S(=O)(=O)Nc1noc2cc(Cn3cccn3)cc(OCF)c12)C(F)F

InChI Key InChIKey=ZGZGCHGOOAPHST-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 663025   

TargetHistone acetyltransferase KAT6A [507-778](Human)
Insilico Medicine IP

US Patent
LigandChemical structure of BindingDB Monomer ID 663025BDBM663025(N-(6-((1H-pyrazol-1-yl)methyl)-4-(fluoromethoxy)be...)
Affinity DataIC50: 505nMAssay Description:Inhibition of KAT6A enzymatic activity by test compounds was determined using a radiometric 384-well format assay. A 10-point serial dilution of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent