BDBM667328 N-(3,6-dichloro-9H-xanthen- 9-yl)-2-oxo-6- (trifluoromethyl)-1,2- dihydropyridine-3- carboxamide::US11957687, Compound 50

SMILES FC(F)(F)c1ccc(C(=O)NC2c3ccc(Cl)cc3Oc3cc(Cl)ccc23)c(=O)[nH]1

InChI Key InChIKey=CSWLBAWVPPLEGS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 667328   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667328(US11957687, Compound 50 | N-(3,6-dichloro-9H-xanth...)
Affinity DataIC50: 120nMAssay Description:Compounds of the disclosure were screened for their ability to block HSD17B13 function using an enzymatic blocking assay. HSD17B13 activity was quant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667328(US11957687, Compound 50 | N-(3,6-dichloro-9H-xanth...)
Affinity DataIC50: 4.22E+3nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B1 function, an enzymatic blocking assay was performed. For the assay, HSD17B1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667328(US11957687, Compound 50 | N-(3,6-dichloro-9H-xanth...)
Affinity DataIC50: 5.16E+3nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B2 function, an enzymatic blocking assay was performed. For the assay, HSD17B2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target3-hydroxyacyl-CoA dehydrogenase type-2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667328(US11957687, Compound 50 | N-(3,6-dichloro-9H-xanth...)
Affinity DataIC50: 3.00E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B10 function, an enzymatic blocking assay was performed. For the assay, HSD17B1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667328(US11957687, Compound 50 | N-(3,6-dichloro-9H-xanth...)
Affinity DataIC50: 1.00E+5nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B4 function, an enzymatic blocking assay was performed. For the assay, HSD17B4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent