BDBM667812 1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-3-(hydroxymethyl)pyridin-4-yl)urea::US11958846, Example 8

SMILES OCc1c(F)nccc1NC(=O)Nc1cc(ns1)C(F)F

InChI Key InChIKey=IHWHEWSGCAIVIM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 667812   

TargetTranscription activator BRG1 [658-1361](Human)
Novartis

US Patent
LigandPNGBDBM667812(US11958846, Example 8 | 1-(3-(difluoromethyl)isoth...)
Affinity DataIC50: 19nMAssay Description:Compound inhibition of ATPase activity of Brm ATPase-SnAC (636-1331) was measured by using the ADP-Glo assay kit from Promega (V6930). 120 nL of comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

LigandPNGBDBM667812(US11958846, Example 8 | 1-(3-(difluoromethyl)isoth...)
Affinity DataIC50: 90nMAssay Description:All subsequent reagent additions were performed using a MultiFlo FX Multi-Mode Dispenser. Assay buffer was 20 mM HEPES pH 7.5, 1 mM MgCl2, 20 mM KCl,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent