BDBM668161 US20240124450, Example 14::US20240124450, Example 15A::US20240124450, Example 15B

SMILES CSc1cc(cc(OC[C@@]2(N)CCCC(C)(C)C2)c1C#N)-c1cnc2cccc(C#N)n12

InChI Key InChIKey=VATIVDMNNPRBCN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 668161   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 0.200nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 0.600nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 0.600nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 1.10nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 1.20nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 1.5nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 2.10nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 2.5nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandPNGBDBM668161(US20240124450, Example 14 | US20240124450, Example...)
Affinity DataIC50: 2.90nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent