BDBM668362 2-((1r,4r)-4-((3-(3-(furan-2-yl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol ::US20240124469, Compound 48

SMILES CC(C)(O)[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(-c5ccco5)c4)n3n2)CC1

InChI Key InChIKey=SIDJSVHZOQKDIN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 668362   

TargetSerine/threonine-protein kinase pim-1(Human)
Hangzhou Biosun Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 668362BDBM668362(US20240124469, Compound 48 | 2-((1r,4r)-4-((3-(3-(...)
Affinity DataIC50: 55nMAssay Description:PIM1, PIM2, and PIM3 (all three kinases are from Carna) were each prepared with 1× Kinase buffer into a kinase solution at a concentration that was 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Hangzhou Biosun Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 668362BDBM668362(US20240124469, Compound 48 | 2-((1r,4r)-4-((3-(3-(...)
Affinity DataIC50: 550nMAssay Description:PIM1, PIM2, and PIM3 (all three kinases are from Carna) were each prepared with 1× Kinase buffer into a kinase solution at a concentration that was 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Hangzhou Biosun Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 668362BDBM668362(US20240124469, Compound 48 | 2-((1r,4r)-4-((3-(3-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:PIM1, PIM2, and PIM3 (all three kinases are from Carna) were each prepared with 1× Kinase buffer into a kinase solution at a concentration that was 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
US Patent