BDBM669900 Production of 3-(5-acetylthiophen-2-yl)-3-(3-{[(R)-4-ethyl-9-fluoro-1,1-dioxide-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl]methyl}-4-methylphenyl)-2,2-dimethylpropanoic acid ::US20240132519, Compound 9

SMILES CC[C@@H]1CN(Cc2cc(ccc2C)C(c2ccc(s2)C(C)=O)C(C)(C)C(O)=O)S(=O)(=O)c2c(F)cccc2O1

InChI Key InChIKey=FCRXBQKBRLUUAQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 669900   

LigandPNGBDBM669900(US20240132519, Compound 9 | Production of 3-(5-ace...)
Affinity DataIC50: 0.300nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent