BDBM670780 (6R)-3-(3-(difluoromethoxy)phenyl)- 1-(5-fluoropyridin-2-yl)-N-(3- methyltetrahydrofuran-3-yl)-4,5,6,7- tetrahydro-1H-indazole-6- carboxamide (faster eluting with OD- H column, 30% iPrOH (0.1% DEA)/CO2)::US20240140938, Example 6a::US20240140938, Example 6b

SMILES CC1(CCOC1)NC(=O)[C@@H]1CCc2c(C1)n(nc2-c1cccc(OC(F)F)c1)-c1ccc(F)cn1

InChI Key InChIKey=BCZOUFJVJGAABH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670780   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670780((6R)-3-(3-(difluoromethoxy)phenyl)- 1-(5-fluoropyr...)
Affinity DataIC50: 2nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670780((6R)-3-(3-(difluoromethoxy)phenyl)- 1-(5-fluoropyr...)
Affinity DataIC50: 37.4nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent