BDBM670787 ((R)-3-(5-(difluoromethoxy)-2- fluorophenyl)-1-(3,5-difluoropyridin- 2-yl)-N-(3-methyl-1,1- dioxidothietan-3-yl)-4,5,6,7- tetrahydro-1H-indazole-6- carboxamide::US20240140938, Example 11

SMILES CC1(CS(=O)(=O)C1)NC(=O)[C@@H]1CCc2c(C1)n(nc2-c1cc(OC(F)F)ccc1F)-c1ncc(F)cc1F

InChI Key InChIKey=HAIANXCAVSPIAG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670787   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670787(US20240140938, Example 11 | ((R)-3-(5-(difluoromet...)
Affinity DataIC50: 0.330nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670787(US20240140938, Example 11 | ((R)-3-(5-(difluoromet...)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of human DGAT2 expressed in expressed in baculovirus infected Sf9 insect cells by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed