BDBM677853 US20240174674, Compound 88

SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)OC(C)(C)C)[C@@H](O)C2)c2c3cn[nH]c3nn2c1

InChI Key InChIKey=OTYQHTKXCUUPLB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 677853   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677853(US20240174674, Compound 88)
Affinity DataIC50: 0.100nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677853(US20240174674, Compound 88)
Affinity DataIC50: 0.200nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677853(US20240174674, Compound 88)
Affinity DataIC50: 7.80nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent