BDBM677953 US20240174674, Compound 297

SMILES COc7ccc(CN1C6CC1CN(c5ccc(c3cc(OCC(F)(F)F)cn4nc2[nH]ncc2c34)cn5)C6)cn7

InChI Key InChIKey=NYFLTHPPVNMNFL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 677953   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 0.100nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 0.200nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 1.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 5.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Applied Pharmaceutical Science

US Patent
LigandPNGBDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 9.60nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent