BDBM678422 4-(2-cyclopentyl-2,8-diazaspiro[4.5]decan-8-yl)-2-(3-methyl-1H-pyrazol-4-yl)pyrido[3,4-d]pyrimidine ::US20240174696, Compound 147

SMILES Cc1n[nH]cc1-c1nc(N2CCC3(CCN(C3)C3CCCC3)CC2)c2ccncc2n1

InChI Key InChIKey=UAPFATLGRSUIKX-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 678422   

TargetSerine/threonine-protein kinase LATS1 [590-1130](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM678422(US20240174696, Compound 147 | 4-(2-cyclopentyl-2,8...)
Affinity DataKi:  0.0130nMAssay Description:The LATS1 biochemical assay was performed using the HTRF KinEASE-STK S1 Kit (Cisbio, Cat #62ST1PEC), following the protocol from the manufacturer. Co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetSerine/threonine-protein kinase LATS2(Human)
Genentech

US Patent
LigandPNGBDBM678422(US20240174696, Compound 147 | 4-(2-cyclopentyl-2,8...)
Affinity DataKi:  0.0560nMAssay Description:Human LATS2 catalytic domain which contains the amino acids G553-V1088 (accession NP_055387) was purified in-house. The LATS2 catalytic domain was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent