BDBM681308 N-(4-((R*)-2-(2,3-Difluorophenyl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide (Isomer 2)::US20240199558, Example 144::WO2024083933, Example 144

SMILES CC(C)C[C@H](CO)Nc1nc(C[C@@H](C)c2cccc(F)c2F)nc(NS(C)(=O)=O)n1

InChI Key InChIKey=UVSCEDOEAWZVGP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 681308   

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 681308BDBM681308(US20240199558, Example 144 | N-(4-((R*)-2-(2,3-Dif...)
Affinity DataIC50: 13nMAssay Description:CHO-hCX3CR1 membranes (5 μg per well) together with different concentrations of antagonistic compound were incubated in 50 mM HEPES (pH 7.4), 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetCX3C chemokine receptor 1(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 681308BDBM681308(US20240199558, Example 144 | N-(4-((R*)-2-(2,3-Dif...)
Affinity DataIC50: 104nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
US Patent