BDBM682234 7-fluoro-8-(6-((2-(4-fluoropiperidin-1-yl)ethoxy)methyl)pyridin-3-yl)-1-isopropyl-3-methyl-1H-imidazo[4,5-c]cinnolin-2(3H)-one::US20240207263, Ref Compd 1

SMILES CC(C)n1c2c(nnc3cc(F)c(cc23)-c2ccc(COCCN3CCC(F)CC3)nc2)n(C)c1=O

InChI Key InChIKey=ODTOPIDGJZLIEA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 682234   

TargetSerine-protein kinase ATM(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682234(US20240207263, Ref Compd 1 | 7-fluoro-8-(6-((2-(4-...)
Affinity DataIC50: 25nMAssay Description:ATM (Millipore, Cat. No. 14-933) enzyme solution was prepared in 1x kinase base buffer. 10 ul of 2x enzyme solution was transferred to each well of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682234(US20240207263, Ref Compd 1 | 7-fluoro-8-(6-((2-(4-...)
Affinity DataIC50: 25nMAssay Description:ATM (Millipore, Cat. No. 14-933) enzyme solution was prepared in 1× kinase base buffer. 10 μl of 2× enzyme solution was transferred to each well of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682234(US20240207263, Ref Compd 1 | 7-fluoro-8-(6-((2-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Solution of mTOR enzymes (Millipore, Cat. No. 14-770, Lot. No. 2052551) was prepared in 1× kinase buffer at 4-fold of the final concentration (final ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

LigandPNGBDBM682234(US20240207263, Ref Compd 1 | 7-fluoro-8-(6-((2-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of PI3Kα (Invitrogen, Cat. No. PV4788), PIK3Cδ (Invitrogen, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

LigandPNGBDBM682234(US20240207263, Ref Compd 1 | 7-fluoro-8-(6-((2-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of PI3Kα (Invitrogen, Cat. No. PV4788), PIK3Cδ (Invitrogen, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

LigandPNGBDBM682234(US20240207263, Ref Compd 1 | 7-fluoro-8-(6-((2-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of PI3Kα (Invitrogen, Cat. No. PV4788), PIK3Cδ (Invitrogen, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

LigandPNGBDBM682234(US20240207263, Ref Compd 1 | 7-fluoro-8-(6-((2-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:PI3Kα (p110α/p85a), PIK3C δ, PIK3Cβ (p110β), PIK3Cγ (pp110γ) kinase reaction solutions of PI3Kα (Invitrogen, Cat. No. PV4788), PIK3Cδ (Invitrogen, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM682234(US20240207263, Ref Compd 1 | 7-fluoro-8-(6-((2-(4-...)
Affinity DataIC50: 1.00E+4nMAssay Description:ATR enzyme was made by ChemPartner (batch: CP-ATR-20161102-M2). 2× enzyme solutions were prepared in 1× kinase base buffer. 10 μl of 2× enzyme soluti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
US Patent