BDBM684819 4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-::US20240228512, Example 1

SMILES C[C@@H](N1CCOc2nc(c(F)c3nc(OCC45CCN4CC(F)(F)C5)nc1c23)-c1cc(O)cc2cccc(C#C)c12)c1cccnc1N

InChI Key InChIKey=OSPVNOVMLNCVID-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 684819   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684819(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- | US2024...)
Affinity DataIC50: 0.100nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684819(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- | US2024...)
Affinity DataIC50: 0.114nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent