BDBM684834 3-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2- (trifluoromethyl)phenyl)-4-fluoro-2- (((6S,8aS)-hexahydro-1H-pyrrolo[2,1- c][1,4]oxazin-6-yl)methoxy)-8,9-dihydro- 10H-7-oxa-1,3,6,10- tetraazacyclohepta[de]naphthalen-10- yl)ethyl)pyridin-2-amine::US20240228512, Example 16

SMILES C[C@@H](N1CCOc2nc(c(F)c3nc(OC[C@@H]4CC[C@H]5COCCN45)nc1c23)-c1cc(N)c(F)c(C)c1C(F)(F)F)c1cccnc1N

InChI Key InChIKey=LAAHTJVHRKKIJP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 684834   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684834(3-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2- (trifluo...)
Affinity DataIC50: 0.0600nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandPNGBDBM684834(3-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2- (trifluo...)
Affinity DataIC50: 0.180nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent