BDBM685750 (R)-1-(3,3-diphenylallyl)-3-(4- methoxyphenyl)-1-(1-(4- methoxyphenyl)ethyl)urea::US12043602, Compound NY0224

SMILES [#6]-[#8]-c1ccc(-[#7]-[#6](=O)-[#7](-[#6]\[#6]=[#6](/c2ccccc2)-c2ccccc2)-[#6@H](-[#6])-c2ccc(-[#8]-[#6])cc2)cc1

InChI Key InChIKey=HBYLSFCBUIJAFT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685750   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685750(US12043602, Compound NY0224 | (R)-1-(3,3-diphenyla...)
Affinity DataIC50: 640nMAssay Description:Table 1: Potency and efficacy of K-RAS inhibition and toxicity of batch1 and 2 compounds. MDCK cells co-expressing GFP-K-RASG12V and mCherry-CAAX wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent