BDBM685830 US12043602, Compound PW358

SMILES [#6]-[#8]-c1cc(cc(-[#8]-[#6])c1-[#8]-[#6])-[#6](=[#6]/[#6]-[#7](-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-1)-[#6@H](-[#6])-c1ccc(F)cc1)\c1cc(-[#8]-[#6])c(-[#8]-[#6])c(-[#8]-[#6])c1

InChI Key InChIKey=OKUVRJCZBJFMSD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685830   

TargetGTPase KRas [G12V](Human)
University of Texas

US Patent
LigandPNGBDBM685830(US12043602, Compound PW358)
Affinity DataIC50: 1.02E+3nMAssay Description:Table 7: Potency and efficacy of K-RAS inhibition and toxicity ofbatch 5 compounds. MDCK cells co-expressing GFP-K-RASG12V andmCherry-CAAX were grown...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
US Patent