BDBM686464 2-(1-((1R,2R)-2-((2-(2,6- dioxopiperidin-3-yl)-1- oxoisoindolin-5- yl)oxy)cyclohexyl)azetidin-3-yl)- 5-fluorobenzonitrile::US20240246935, Example 43

SMILES Fc1ccc(C2CN(C2)[C@@H]2CCCC[C@H]2Oc2ccc3C(=O)N(Cc3c2)C2CCC(=O)NC2=O)c(c1)C#N

InChI Key InChIKey=IXURQSOFGHUSSF-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 686464   

TargetProtein cereblon(Human)
Plexium, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 686464BDBM686464(US20240246935, Example 43 | 2-(1-((1R,2R)-2-((2-(2...)
Affinity DataEC50:  42nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent