BDBM686510 1-(5-(((1S,2S)-2-(3-(3- fluorophenyl)azetidin-1- yl)cyclohexyl)oxy)-1- oxoisoindolin-2-yl)-3- azabicyclo[3.1.1]heptane-2,4- dione::US20240246935, Example 89

SMILES O=C1NC(=O)C2(N3Cc4cc(O[C@H]5CCCC[C@@H]5N5CC(c6cccc(F)c6)C5)ccc4C3=O)CC1C2

InChI Key InChIKey=ZEQMCSZYRVXYQW-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 686510   

TargetProtein cereblon(Human)
Plexium, Inc.

US Patent
LigandChemical structure of BindingDB Monomer ID 686510BDBM686510(US20240246935, Example 89 | 1-(5-(((1S,2S)-2-(3-(3...)
Affinity DataEC50:  6.81E+3nMAssay Description:Cereblon target engagement was monitored by Bioluminescence Resonance Energy Transfer (BRET) in transfected HEK-293T cells using the NanoBRET TE Intr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent