BDBM692036 (R)-6-(1-((6-cyclopropyl-2-methyl-1,7-dioxo-1,2,6,7-tetrahydropyrido[3,4-d]pyridazin-4-yl)amino)ethyl)-1-methyl-1H-indazole-3-carbonitrile (Example 25, stereochemistry is arbitrarily assigned) and (S)-6-(1-((6-cyclopropyl-2-methyl-1,7-dioxo-1,2,6,7-tetrahydropyrido[3,4-d]pyridazin-4-yl)amino)ethyl)-1-methyl-1H-indazole-3-carbonitrile (example 26, stereochemistry is arbitrarily assigned)::US20240279221, Example 25::US20240279221, Example 26
SMILES C[C@H](Nc1nn(C)c(=O)c2cc(=O)n(cc12)C1CC1)c1ccc2c(nn(C)c2c1)C#N
InChI Key InChIKey=WKEIHIDTUGXFNB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 692036
Affinity DataKd: 225nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
Affinity DataIC50: 3.86E+3nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair
Affinity DataKd: >5.00E+4nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of the SOS1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl Ac...More data for this Ligand-Target Pair