BDBM693389 N-(4-((3-(2-((4-(dimethylamino)-3- fluorocyclohexyl)amino)pyrimidin-4- yl)pyridin-2-yl)oxy)-2,3,6- trifluorophenyl)-1- phenylmethanesulfonamide::US12071425, Compound 307

SMILES CN(C)[C@@H]5CC[C@@H](Nc4nccc(c1cccnc1Oc3cc(F)c(NS(=O)(=O)Cc2ccccc2)c(F)c3F)n4)C[C@H]5F

InChI Key InChIKey=DPNSHTKNFHFSJU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 693389   

LigandChemical structure of BindingDB Monomer ID 693389BDBM693389(N-(4-((3-(2-((4-(dimethylamino)-3- fluorocyclohexy...)
Affinity DataIC50: 0.310nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent