BDBM693409 N-(4-((3-(2-((5-cyclopropylpiperidin-3- yl)amino)pyrimidin-4-yl)pyridin-2- yl)oxy)-2,3,6-trifluorophenyl)-1-(2- fluorophenyl)methanesulfonamide::US12071425, Compound 327

SMILES O=S(=O)(Cc1ccccc1F)Nc6c(F)cc(Oc2ncccc2c5ccnc(N[C@H]4CNC[C@@H](C3CC3)C4)n5)c(F)c6F

InChI Key InChIKey=MJJTWNUFXPHOLB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 693409   

LigandChemical structure of BindingDB Monomer ID 693409BDBM693409(N-(4-((3-(2-((5-cyclopropylpiperidin-3- yl)amino)p...)
Affinity DataIC50: 0.260nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent