BDBM693424 1-phenyl-N-(2,3,6-trifluoro-4-((3-(2-((5- (1-fluoroethyl)piperidin-3- yl)amino)pyrimidin-4-yl)pyridin-2- yl)oxy)phenyl)methanesulfonamide hydrochloride::US12071425, Compound 342::US12071425, Compound 343::US12071425, Compound 344::US12071425, Compound 345::US12071425, Compound 346::US12071425, Compound 347::US12071425, Compound 348::US12071425, Compound 349

SMILES CC(F)C1CNCC(C1)Nc1nccc(n1)-c1cccnc1Oc1cc(F)c(NS(=O)(=O)Cc2ccccc2)c(F)c1F

InChI Key InChIKey=MHLJTIGAGKBYBE-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 693424   

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 0.160nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 0.170nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 0.780nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 19nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 49nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 72nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent

LigandPNGBDBM693424(US12071425, Compound 344 | US12071425, Compound 34...)
Affinity DataIC50: 210nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/6/2024
Entry Details
US Patent