BDBM693430 1-phenyl-N-(2,3,6-trifluoro-4-((3-(2-((5- (1-fluoroethyl)piperidin-3- yl)amino)pyrimidin-4-yl)pyridin-2- yl)oxy)phenyl)methanesulfonamide::US12071425, Compound 348

SMILES C[C@H](F)[C@@H]5CNC[C@@H](Nc4nccc(c1cccnc1Oc3cc(F)c(NS(=O)(=O)Cc2ccccc2)c(F)c3F)n4)C5

InChI Key InChIKey=MHLJTIGAGKBYBE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 693430   

LigandChemical structure of BindingDB Monomer ID 693430BDBM693430(1-phenyl-N-(2,3,6-trifluoro-4-((3-(2-((5- (1-fluor...)
Affinity DataIC50: 0.200nMAssay Description:To determine the affinity of compound binding to the kinase domain of IRE1 alpha, a Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) co...More data for this Ligand-Target Pair
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Date in BDB:
12/6/2024
Entry Details
US Patent