BDBM694187 8,9-dichloro-7-(3-fluoro-2-pyridyl)-5H-pyrimido[1,2-a][1,4]benzodiazepin-3-one::US20240287082, Example 3

SMILES Fc1cccnc1C1=NCc2nc(=O)ccn2-c2ccc(Cl)c(Cl)c12

InChI Key InChIKey=PUYIGSMZWSIUSL-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694187   

LigandPNGBDBM694187(8,9-dichloro-7-(3-fluoro-2-pyridyl)-5H-pyrimido[1,...)
Affinity DataKi:  10.3nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694187(8,9-dichloro-7-(3-fluoro-2-pyridyl)-5H-pyrimido[1,...)
Affinity DataKi:  112nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694187(8,9-dichloro-7-(3-fluoro-2-pyridyl)-5H-pyrimido[1,...)
Affinity DataKi:  183nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694187(8,9-dichloro-7-(3-fluoro-2-pyridyl)-5H-pyrimido[1,...)
Affinity DataKi:  2.19E+3nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent