BDBM694213 (5S)-8-chloro-7-(2,6-difluorophenyl)-2-(hydroxymethyl)-5-methyl-9-(trifluoromethyl)-5H-pyrimido[1,2-a][1,4]benzodiazepin-3-one::US20240287082, Example 29

SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(ccc2-n2cc(CO)c(=O)nc12)C(F)(F)F

InChI Key InChIKey=HMJHLNGMEQISSL-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694213   

LigandPNGBDBM694213(US20240287082, Example 29 | (5S)-8-chloro-7-(2,6-d...)
Affinity DataKi:  11.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694213(US20240287082, Example 29 | (5S)-8-chloro-7-(2,6-d...)
Affinity DataKi:  44.6nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694213(US20240287082, Example 29 | (5S)-8-chloro-7-(2,6-d...)
Affinity DataKi:  113nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

LigandPNGBDBM694213(US20240287082, Example 29 | (5S)-8-chloro-7-(2,6-d...)
Affinity DataKi:  1.31E+4nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent