BDBM694483 US20240293412, Compound TABLE2.36

SMILES CN1CCN(C[C@H]1C(=O)NCc1ccc2sccc2c1)c1ncnc2nn(cc12)-c1ccc(C)c(F)c1

InChI Key InChIKey=XQQWDPYKSGUYNU-UHFFFAOYSA-N

Data  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 694483   

TargetNicotinamide phosphoribosyltransferase(Human)
University of Illinois

US Patent
LigandPNGBDBM694483(US20240293412, Compound TABLE2.36)
Affinity DataEC50:  18nMAssay Description:All FP measurements were performed at room temperature in PBS buffer containing 0.01% Triton-X 100 and 1% DMSO in black 384-well plates. Measurements...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
University of Illinois

US Patent
LigandPNGBDBM694483(US20240293412, Compound TABLE2.36)
Affinity DataEC50:  18nMAssay Description:Positive allosteric modulation of C-terminal His6-tagged wild type human NAMPT using NAM and PRPP as substrates measured for 1 hr by NMNAT1-coupled e...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Illinois

US Patent
LigandPNGBDBM694483(US20240293412, Compound TABLE2.36)
Affinity DataKd:  90nMAssay Description:Displacement of FP-probe ZN-2-102 from C-terminal His6-tagged wild type human NAMPT rear channel assessed as dissociation constant by fluorescence po...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed