BDBM696489 3-[3-chloro-2-(difluoromethoxy)anilino]-2-(3-{[3,3-dimethyloxetan-2-yl]methoxy}pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one::US20240307362, Example 71::US20240307362, Example 72::US20240307362, Example 73

SMILES CC1(C)COC1COc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(Cl)c1OC(F)F

InChI Key InChIKey=RTFDMXFTQZCKAO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 696489   

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696489(US20240307362, Example 71 | US20240307362, Example...)
Affinity DataIC50: 0.208nMAssay Description:A recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR variant (amino acids R669 to A1210 with insert...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696489(US20240307362, Example 71 | US20240307362, Example...)
Affinity DataIC50: 0.526nMAssay Description:A recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR variant (amino acids R669 to A1210 with insert...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696489(US20240307362, Example 71 | US20240307362, Example...)
Affinity DataIC50: 1.54nMAssay Description:A recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR variant (amino acids R669 to A1210 with insert...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696489(US20240307362, Example 71 | US20240307362, Example...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696489(US20240307362, Example 71 | US20240307362, Example...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetMitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM696489(US20240307362, Example 71 | US20240307362, Example...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent