BDBM696646 N-(5-(4-(2-hydroxypropan-2- yl)-2-azabicyclo[2.1.1]hexan-2- yl)-2-(trifluoromethyl)pyridin- 3-yl)-6-(1-(2,2,2-trifluoroethyl)- 1H-pyrazol-4-yl)picolinamide::US20240308980, Ex-1.11

SMILES CC(C)(O)C12CC(C1)N(C2)c1cnc(c(NC(=O)c2cccc(n2)-c2cnn(CC(F)(F)F)c2)c1)C(F)(F)F

InChI Key InChIKey=ULXZQNNOQOKSIQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 696646   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM696646(N-(5-(4-(2-hydroxypropan-2- yl)-2-azabicyclo[2.1.1...)
Affinity DataIC50: 1.54E+3nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent