BDBM696659 (R, R) or (S, S) or (S, R), or (R, S) N-(5-(4-hydroxy-2- methylpyrrolidin-1-yl)-2- (trifluoromethyl)pyridin-3-yl)- 6-(1-(2,2,2-trifluoroethyl)-1H- pyrazol-4-yl)picolinamide::US20240308980, Ex-1.24::US20240308980, Ex-1.25::US20240308980, Ex-1.26

SMILES CC1CC(O)CN1c1cnc(c(NC(=O)c2cccc(n2)-c2cnn(CC(F)(F)F)c2)c1)C(F)(F)F

InChI Key InChIKey=VGGIYNPNQCEJEE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 696659   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM696659(US20240308980, Ex-1.24 | (R, R) or (S, S) or (S, R...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM696659(US20240308980, Ex-1.24 | (R, R) or (S, S) or (S, R...)
Affinity DataIC50: 1.20E+3nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM696659(US20240308980, Ex-1.24 | (R, R) or (S, S) or (S, R...)
Affinity DataIC50: 1.65E+3nMAssay Description:Compound potency against LRRK2 kinase activity was determined using LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA) using a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent