BDBM698800 (S)-(2-((1- ((dimethylamino)methyl)cyclopropyl) methoxy)-4-(3-methylpiperidin-1-yl)- 5,7-dihydro-6H-pyrrolo[3,4-d] pyrimidin-6-yl)(3-hydroxy-8- iodonaphthalen-1-yl)methanone::US20240317759, Example 10

SMILES CC1(C)CCN1C(=O)c1cnc(N[C@H]2Cc3cc(Cl)cc(C#N)c3C2)nc1

InChI Key InChIKey=LRTTUONDTSQFRC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 698800   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 698800BDBM698800((S)-6-chloro-2-((5-(2,2- dimethylazetidine-1- carb...)
Affinity DataIC50: 6.5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent