BDBM698847 (2-((1- ((dimethylamino)methyl)cyclopropyl) methoxy)-4-(1-oxa-7-azaspiro[4.5] decan-7-yl)-5,7-dihydro- 6H-pyrrolo[3,4- d]pyrimidin-6-yl)(3-hydroxy-8- iodonaphthalen-1-yl)methanone::US20240317759, Example 57

SMILES CN1CCN(c2ccc(Nc3ncc4ccc5onc(C6CCCC6)c5c4n3)nc2)CC1

InChI Key InChIKey=XVPAZMKEMNXQHH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698847   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698847BDBM698847(9-cyclopentyl-N-(5-(4-methylpiperazin- 1-yl)pyridi...)
Affinity DataIC50: 5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698847BDBM698847(9-cyclopentyl-N-(5-(4-methylpiperazin- 1-yl)pyridi...)
Affinity DataIC50: 15nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent