BDBM698852 (R)-(2-((1- ((dimethylamino)methyl)cyclopropyl) methoxy)-4-(2-(hydroxymethyl)-1,4- oxazepan-4-yl)-5,7-dihydro-6H- pyrrolo[3,4-d]pyrimidin-6-yl)(3- hydroxy-8-iodonaphthalen-1- yl)methanone::US20240317759, Example 62

SMILES CCN1CCN(c2ccc(Nc3ncc4ccc5onc(C(C)C)c5c4n3)cc2)CC1

InChI Key InChIKey=APEHSBSAQFMZHK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 698852   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698852BDBM698852(N-(4-(4-ethylpiperazin-1-yl)phenyl)- 9-isopropylis...)
Affinity DataIC50: 2nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698852BDBM698852(N-(4-(4-ethylpiperazin-1-yl)phenyl)- 9-isopropylis...)
Affinity DataIC50: 4nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698852BDBM698852(N-(4-(4-ethylpiperazin-1-yl)phenyl)- 9-isopropylis...)
Affinity DataIC50: 5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent