BDBM698866 (2-((1- ((dimethylamino)methyl)cyclopropyl) methoxy)-4-(3-hydroxy-3- (trifluoromethyl)piperidin-1-yl)-5,7- dihydro-6H-pyrrolo[3,4-d]pyrimidin-6- yl)(3-hydroxy-8-iodonaphthalen-1- yl)methanone formate::US20240317759, Example 76

SMILES CC(C)c1noc2ccc3cnc(NC4C=C(S(N)(=O)=O)C=CC4)nc3c12

InChI Key InChIKey=PLHZBULQJCKXLK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 698866   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698866BDBM698866(3-((9-isopropylisoxazolo[5,4-h]quinazolin-2-yl)ami...)
Affinity DataIC50: 2nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698866BDBM698866(3-((9-isopropylisoxazolo[5,4-h]quinazolin-2-yl)ami...)
Affinity DataIC50: 6nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Chengdu Cynogen Bio-Pharmaceutical Technology Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 698866BDBM698866(3-((9-isopropylisoxazolo[5,4-h]quinazolin-2-yl)ami...)
Affinity DataIC50: 10nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2026
Entry Details
US Patent