BDBM698925 (R)-(2-((1-((dimethyl- amino)methyl)cyclo- propyl)methoxy)- 4-(3-hydroxy-3- methylpiperidin-1-yl)-5,7- dihydro-6H-pyrrolo[3,4- d]pyrimidin-6-yl)(8- ethynyl-3- hydroxynaphthalen-1- yl)methanone::US20240317759, Example 134

SMILES COc1nc(NC(=O)Cc2ccc(C(F)(F)F)cc2)ccc1C[C@H]1COC(=O)N1

InChI Key InChIKey=FEJLUAZGBFPYKK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 698925   

TargetDNA polymerase(HHV-3)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 698925BDBM698925(US12605369, Compound 1)
Affinity DataIC50: 0.800nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent

TargetDNA polymerase(HHV-5)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 698925BDBM698925(US12605369, Compound 1)
Affinity DataIC50: 8nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2026
Entry Details
US Patent